Table 4 Pharmacokinetic parameters for selenate for all patient cohorts
AUC0–24 h (ng h ml–1) | AUC0–168 h (ng h ml–1) | AUC0–336 h (ng h ml–1) | AUClast (ng h ml–1) | T 1/2 (h) | T max (0−last) (h) | Cmax (0−last) (ng ml–1) | Cmin (0−last) (ng ml–1) | |
|---|---|---|---|---|---|---|---|---|
Single daily dose (mg) | ||||||||
5 | — | — | — | 126.9 | 1.23 | 1 | 56 | 2.78 |
10 | — | — | — | 8311.9 | 1.61 | 1 | 112 | 30.6 |
15 | — | — | — | 440.8 | 1.38 | 0.7 | 154 | 40.3 |
30 | — | — | — | 666.4 | 2.9 | 2.2 | 166 | 65.3 |
Mullti-dose | ||||||||
30 mg (10 mg t.d.s.) | ||||||||
n | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
Mean | 502.39 | 1290.5 | 2049.3 | 2763.37 | 1.72 | 1.43 | 98.13 | 2.86 |
s.d. | 161.92 | 293 | 426.7 | 972.46 | 0.25 | 0.6 | 56.36 | 0.91 |
CV % | 32.23 | 22.7 | 20.8 | 35.19 | 14.8 | 42.05 | 57.43 | 31.85 |
45 mg (15 mg t.d.s.) | ||||||||
n | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Mean | 549.1 | 2232.2 | 8437.1 | 15130.3 | 2.14 | 169.6 | 107.5 | 6.63 |
s.d. | 17.5 | 92.8 | 6884.9 | 13931.5 | 1.34 | 237.1 | 19.2 | 1.99 |
CV % | 3.2 | 4.2 | 81.6 | 92.1 | 62.6 | 139.8 | 17.8 | 29.99 |
60 mg (20 mg t.d.s.) | ||||||||
n | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
Mean | 1232.9 | 7201.1 | 11678.7 | 14354.7 | 3.09 | 2.6 | 165 | 11.23 |
s.d. | 684 | 5892.2 | 9275.6 | 9632 | 1.04 | 1.2 | 72.3 | 5.57 |
CV % | 55.5 | 81.8 | 79.4 | 67.1 | 32.5 | 46.1 | 43.9 | 49.61 |
90 mg (30 mg t.d.s.) | ||||||||
n | 4 | 4 | 3 | 3 | 4 | 4 | 4 | 4 |
Mean | 1313.6 | 9783.1 | 15921.1 | 21521.4 | 2.26 | 13.4 | 218.8 | 18.63 |
s.d. | 163.7 | 1862.6 | 3671.2 | 6843.7 | 0.58 | 23.5 | 90.7 | 8.73 |
CV % | 12.5 | 19 | 23.1 | 31.8 | 25.7 | 174.7 | 41.5 | 46.87 |
