Table 1 Comparative CD70 expression in pancreatic and ovarian cancer cell lines by immunohistochemistry and quantitative FACS

From: Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody–drug conjugate SGN-75

Cell line

Tumor type

CD70 IHC (1C1)

CD70 IHC (5D12)

CD70 receptor numbera ( × 103)

OVCAR-3

Ovarian

1+

1–2+

1.3

SK-OV-3

Ovarian

3+

3+

223

CaOV3

Ovarian

1+

2+

0.3

TOV-21G

Ovarian

1+

1+

2

CAPAN-1

Pancreatic

Negative

Negative

0

CAPAN-2

Pancreatic

Negative

Negative

0

SU86.86

Pancreatic

Negative

Negative

0

Panc-1

Pancreatic

2+

2+

10

HPAF-II

Pancreatic

Negative

Negative

0

MiaPaCa-2/CD70

Pancreatic CD70 transfectant

3+

NDb

366

  1. Abbreviations: IHC=immunohistochemistry; ND=not determined.
  2. a Determined by quantitative FACs.
  3. b No data.