Table 3 p-AMPK status and patient mortality in strata of p-MAPK3/1 status (upper rows) and p-MAPK3/1 status and patient mortality in strata of p-AMPK status (lower rows)
Colorectal cancer-specific mortality | Overall mortality | |||||
|---|---|---|---|---|---|---|
No. of deaths/cases | Univariate HR (95% CI) | Multivariate stage-matched HR (95% CI) | No. of deaths/cases | Univariate HR (95% CI) | Multivariate stage-matched HR (95% CI) | |
p-MAPK3/1 (−) | ||||||
p-AMPK (−) | 59/227 | 1 (referent) | 1 (referent) | 84/227 | 1 (referent) | 1 (referent) |
p-AMPK (+) | 72/242 | 1.14 (0.81–1.61) | 1.22 (0.85–1.75) | 106/242 | 1.20 (0.90–1.60) | 1.31 (0.98–1.76) |
p-MAPK3/1 (+) | ||||||
p-AMPK (−) | 23/57 | 1 (referent) | 1 (referent) | 32/57 | 1 (referent) | 1 (referent) |
p-AMPK (+) | 27/145 | 0.39 (0.23–0.69) | 0.42 (0.24–0.74) | 62/145 | 0.64 (0.42–0.98) | 0.65 (0.42–1.01) |
p-AMPK (−) | ||||||
p-MAPK3/1 (−) | 59/227 | 1 (referent) | 1 (referent) | 84/227 | 1 (referent) | 1 (referent) |
p-MAPK3/1 (+) | 23/57 | 1.75 (1.08–2.82) | 1.94 (1.17–3.24) | 32/57 | 1.67 (1.12–2.50) | 1.88 (1.23–2.86) |
p-AMPK (+) | ||||||
p-MAPK3/1 (−) | 72/242 | 1 (referent) | 1 (referent) | 106/242 | 1 (referent) | 1 (referent) |
p-MAPK3/1 (+) | 27/145 | 0.55 (0.36–0.85) | 0.55 (0.35–0.86) | 62/145 | 0.84 (0.62–1.14) | 0.80 (0.58–1.10) |
Pinteraction (p-AMPK and p-MAPK3/1) | 0.0014 | 0.0017 | 0.016 | 0.0026 | ||
