Table 4 Percentage of patients experiencing worsening/improvement from baseline during the follow-up period in selected scales

From: Short-term health-related quality of life and symptom control with docetaxel, cisplatin, 5-fluorouracil and cisplatin (TPF), 5-fluorouracil (PF) for induction in unresectable locoregionally advanced head and neck cancer patients (EORTC 24971/TAX 323)

 

TPF ( N =148)

PF ( N =147)

P -value for difference

 

N (%)

N (%)

 

Global quality of life a

 ⩾16.6 Points worsening

35 (23.6)

37 (25.2)

0.79

 ⩾25 Points worsening

21 (14.2)

21 (14.3)

1.00

 ⩾16.6 Points improvement

80 (54.1)

69 (46.9)

0.25

 ⩾25 Points improvement

52 (35.1)

40 (27.2)

0.17

Coughing b

 ⩾33.3 Points worsening

19 (12.8)

24 (16.3)

0.41

 ⩾33.3 Points improvement

49 (33.1)

35 (23.8)

0.09

Pain c

 ⩾11.1 Points worsening

29 (19.6)

21 (14.3)

0.28

 ⩾22.2 Points worsening

19 (12.8)

13 (8.8)

0.35

 ⩾11.1 Points improvement

50 (33.8)

42 (28.6)

0.38

 ⩾22.2 Points improvement

40 (27.0)

24 (16.3)

0.03

Speech problems d

 ⩾11.1 Points worsening

34 (23.0)

24 (16.3)

0.19

 ⩾22.2 Points worsening

17 (11.5)

15 (10.2)

0.85

 ⩾11.1 Points improvement

51 (34.5)

43 (29.3)

0.38

 ⩾22.2 Points improvement

35 (23.6)

27 (18.4)

0.32

Swallowing e

 ⩾11.1 Points worsening

18 (12.2)

27 (18.4)

0.15

 ⩾22.2 Points worsening

12 (8.1)

16 (10.9)

0.43

 ⩾11.1 Points improvement

47 (31.8)

39 (26.5)

0.37

 ⩾22.2 Points improvement

31 (20.9)

32 (21.8)

0.89

  1. Abbreviations: TPF=docetaxel, cisplatin, and 5-fluorouracil regimen; PF=cisplatin and 5-fluorouracil regimen.
  2. a Global QoL score may take all values from 0 to 100 distant by 8.3 points (0, 8.3, 16.6, and so on). A shift of more than 10 points means a shift of 16.6 points or more. A shift of more than 20 points means a shift of 25 points or more.
  3. b Coughing score may take all values from 0 to 100 distant by 33.3 points (0, 33.3, 66.6, and so on).
  4. c Pain score may take all values from 0 to 100 distant by 2.8 points.
  5. d Speech score may take all values from 0 to 100 distant by 5.5 points.
  6. e Swallowing score may take all values from 0 to 100 distant by 2.8 points.
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