Table 3 Univariate and multivariate Cox proportional hazard models for overall survival and disease-free survival

From: Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery

 

Overall survival

Disease-free survival

 

Univariate

Multivariate

Univariate

Multivariate

 

HR (95% CI)

P*

HR (95% CI)

P*

HR (95% CI)

P*

HR (95% CI)

P*

Age

1.00 (0.98,1.02)

0.834

  

1.00 (0.98, 1.02)

0.952

  

Gender

 Male

—

   

—

   

 Female

1.19 (0.72,1.94)

0.500

  

1.14 (0.72, 1.78)

0.581

  

Tumour location

 Right

—

   

—

   

 Transverse

0.80 (0.30,2.09)

0.643

  

0.83 (0.34, 1.98)

0.669

  

 Left

1.19 (0.71,1.99)

0.505

  

1.12 (0.70, 1.79)

0.631

  

T stage

 T1

0.40 (0.10, 1.65)

0.205

0.40 (0.09, 1.80)

0.235

0.34 (0.08, 1.39)

0.132

0.34 (0.08, 1.45)

0.144

 T2

0.12 (0.03, 0.49)

0.003

0.32 (0.07, 1.40)

0.131

0.16 (0.05, 0.52)

0.002

0.44 (0.13, 1.53)

0.197

 T3

0.36 (0.20, 0.63)

<0.001

0.34 (0.19, 0.61)

<0.001

0.42 (0.26, 0.70)

0.001

0.41 (0.25, 0.70)

0.001

 T4

—

 

—

 

—

 

—

 

N stage

 N0

—

 

—

 

—

   

 N1

3.74 (1.96,7.12)

<0.001

2.85 (1.43, 5.68)

0.003

2.73 (1.57, 4.73)

<0.001

1.97 (1.10, 3.52)

0.022

 N2

15.02 (7.85,28.75)

<0.001

9.65 (4.60, 20.25)

<0.001

10.22 (5.78, 18.08)

<0.001

6.89 (3.60, 13.17)

<0.001

M stage

 M0

—

 

—

 

—

 

—

 

 M1

14.74 (8.15, 26.67)

<0.001

4.74 (2.00, 11.26)

<0.001

9.93 (4.91, 20.07)

<0.001

4.94 (2.29, 10.67)

<0.001

AJCC stage

 I

—

 

—

 

—

 

—

 

 II

2.08 (0.47,9.20)

0.336

  

2.07 (0.61, 6.96)

0.241

  

 III

9.59 (2.31,39.78)

0.002

  

6.69 (2.07, 21.58)

0.001

  

 IV

48.10 (10.15,228.07)

<0.001

  

37.18 (9.95, 138.97)

<0.001

  

Differentiation

 High

—

 

—

 

—

 

—

 

 Moderate

2.37 (1.34, 4.18)

0.003

1.24 (0.65, 2.36)

0.514

2.26 (1.35, 3.79)

0.002

  

 Low

7.50 (4.11, 13.68)

<0.001

2.28 (1.06, 4.88)

0.034

4.87 (2.64, 8.97)

<0.001

  

Vascular invasion

 No

—

   

—

   

 Yes

5.22 (2.76,9.86)

<0.001

  

4.12 (2.16, 7.86)

<0.001

  

UBD

 Negative

—

 

—

 

—

 

—

 

 Weak

2.62 (1.33,5.15)

0.005

1.33 (0.63, 2.81)

0.453

3.28 (1.78, 6.06)

<0.001

1.82 (0.94, 3.53)

0.075

 Strong

3.21 (1.62,6.37)

0.001

2.31 (1.08, 4.93)

0.030

2.64 (1.38, 5.07)

0.003

2.03 (1.03, 3.98)

0.041

Ki-67

 Negative

—

   

—

   

 Positive

2.17 (1.07,4.38)

0.032

  

2.06 (1.09, 3.89)

0.027

1.88 (0.96, 3.69)

0.065

  1. Abbreviations: AJCC=American Joint Committe on cancer; CI=confidence interval; HR=Hazard ratio; UBD=ubiquitin D.
  2. *P<0.05 indicated that the 95% CI of HR was not including 1.
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