Table 4 Localisation and frequency of tumour recurrence

From: Adjuvant chemoradiotherapy of advanced resectable rectal cancer: results of a randomised trial comparing modulation of 5-fluorouracil with folinic acid or with interferon-α

 

Treatment

 
 

5-FU ( N =282)

5-FU+FA ( N =291)

5-FU+INF α (N =223)

Total ( N =796)

Total number of patients

129

123

97

349

 Recurrence rate (in %)

45.7

42.3

43.5

43.8

Local recurrence (only) (in %)

21 (7.4)

16 (5.5)

18 (8.1)

55 (6.9)

Local and distant recurrence (in %)

18 (6.4)

15 (5.2)

12 (5.4)

45 (5.7)

Distant recurrence (only) (in %)

88 (31.2)

88 (30.2)

63 (28.3)

239 (30.0)

Unknown localisation (in %)

2 (0.7)

4 (1.4)

4 (1.8)

10 (1.3)

Distant metastases (events) a

 Liver

60

54

42

156

 Lung

41

35

25

101

 Peritoneum

16

8

8

32

 Bone

2

11

4

17

 Other locations

23

22

17

62

  1. Abbreviations: FA=folinic acid; 5-FU=5-fluorouracil; IFNα=interferon-α.
  2. aOwing to the fact that some patients showed more than one location of distant metastases, the total number of distant metastases is higher than the patient number.
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