Figure 3

Altered gene expression of Wilms' tumour 1 (WT1) target genes and human telomerase reverse transcriptase (hTERT) transcriptional regulators by WT1 overexpression in TK-10 cells detected using expression array analysis. Network analysis was performed based on array data using the Metacore GeneGo software. Increased gene expression is indicated by a filled red circle on the upper right corner of each network object, whereas a blue dot indicates downregulation (⩾2-fold, P<0.01 compared with control). Gene/protein objects are represented by various shapes and colours depending on their functional annotations. Colours of the lines indicate inhibition (red) and activation (green), and gray arrows represent unspecified interactions (e.g., promoter binding).