Figure 2
From: Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas
Comparison of DNA alteration frequency for lung squamous cell carcinoma (SqCC) from arsenic-exposed vs non-exposed patients. Genome profiles were generated for 52 lung SqCC biopsies derived from 22 arsenic-exposed smoker and never-smoker patients from Northern Chile (red), and 30 current and ex-smoker North American patients without known arsenic exposure or non-exposure (blue). Data from each patient were aligned and frequency of DNA gain/loss for each bacterial artificial chromosome (BAC) clone was calculated across the complete sample set. Frequency of alteration results for exposed and non-exposed SqCC cases have been overlaid in this figure. Results in yellow denote a region of overlapping alteration status in both groups. The magnitude of red and blue bars represents percentage of samples exhibiting corresponding alteration (0–100%, with blue vertical lines representing 50% frequency). DNA gains and losses are represented to the right and left of each chromosome, respectively. Analysis was restricted to autosomes, with any differences based on sex subtracted from further analysis (see Materials and Methods). Chr., chromosome.
