Table 3 IRs of hospitalisation for VTEa per 1000 person-years in the cancer cohort (n=40 994) and aRRsb of hospitalisation for venous thromboembolism in the cancer cohort compared with the general-population (n=204 970) (DCR, 1997–2003)c

From: Hospitalisation for venous thromboembolism in cancer patients and the general population: a population-based cohort study in Denmark, 1997–2006

Characteristic

N

IR (95% CI)

aRR b (95% CI)

Cancer stage c

 Stage I

1240

44 (2.7–7.1)

2.9 (1.5–5.5)

 Stage II

14520

44.9 (4.0–5.7)

2.9 (2.4–3.5)

 Stage III

10499

11.1 (9.7–12.7)

7.5 (6.0–9.4)

 Stage IV

9125

27.7 (243.0–32.0)

17.1 (12.6–23.3)

 Unspecified

5610

12.2 (10.1–14.8)

5.6 (4.1–7.5)

Treatment c,d

 No/symptomatic

8565

20.8 (17.3–25.0)

8.4 (6.2–11.4)

 Chemotherapy only

3026

23.1 (19.0–28.1)

18.5 (11.9–28.7)

 Radiation only

2512

10.1 (7.2–14.1)

8.9 (5.0–16.0)

 Surgery only

16564

6.5 (5.7–7.3)

3.2 (2.7- 3.8)

 Othere

781

13.4 (7.6–23.7)

6.0 (2.3–15.6)

 Combination therapy

8625

8.5 (7.3–9.9)

8.6 (6.7–11.1)

 Unspecified

921

9.2 (4.8–17.6)

5.8 (2.1–16.6)

Treatment including c

 No/symptomatic

8565

20.8 (17.3–25.0)

8.4 (6.2–11.4)

 Chemotherapy

7154

14.0 (12.2–16.2)

16.2 (12.0–21.7)

 Radiation

6943

8.2 (6.8–9.9)

7.9 (5.8–10.7)

 Surgery

24525

7.0 (6.3–7.7)

4.1 (3.6- 4.7)

 Othere

781

13.4 (7.6–23.7)

6.0 (2.3–15.6)

 Unspecified

921

9.2 (4.8–17.6)

5.8 (2.1–16.6)

  1. Abbreviations: aRR=adjusted relative risk; CI=confidence interval; DCR=Danish Cancer Registry; IR=incidence rate; VTE=venous thromboembolism.
  2. Please see Supplementary Information for IR and RR by time since diagnosis/index date.
  3. aWe excluded VTEs that occurred in the year before diagnosis/ index date.
  4. bAdjusted for age, sex, myocardial infarction, congestive heart failure, peripheral vascular disease, chronic obstructive pulmonary disease, inflammatory bowel disease, peptic ulcer disease, liver disease, renal disease, diabetes, obesity, acute pancreatitis, alcoholism and hypertension when the number of VTE events for a given comorbidity was sufficient.
  5. cTo obtain data on cancer stage and treatment, analyses are based on cancer patients in the DCR and their matched members of the general-population cohort.
  6. Mutually–exclusive treatment categories
  7. eOthers describe treatment other than chemotherapy, radiation and/or surgery. This includes cryocoagulation, anti-hormone therapy and other treatments not further specified.