Table 4 Hazard ratio (HR) and 95% confidence interval (CI) of breast cancer according to weight change from age 20 years to the current age

From: Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study

   

Age-adjusted model

Multivariate-adjusted model a

Weight change (kg)

Person-years

Cases

HR

95% CI

HR

95% CI

⩽−5

19760

5

0.31

0.10–0.94

0.35

0.11–1.10

−5< ⩽−2

16128

13

0.98

0.41–2.36

1.05

0.43–2.55

−2< <+2

9714

8

1.00

(Reference)

1.00

(Reference)

+2⩽ <+5

18765

11

0.71

0.29–1.77

0.70

0.28–1.75

+5⩽ <+8

22857

21

1.12

0.49–2.52

1.09

0.48–2.47

+8⩽ <+12

20100

19

1.15

0.50–2.62

1.10

0.48–2.53

+12⩽

22567

31

1.67

0.77–3.63

1.55

0.70–3.45

P for trend

   

0.0002

 

0.0086

P for weight loss trend

   

0.03

 

0.04

P for weight gain trend

   

0.02

 

0.05

  1. aAdjusted for age (continuous variable), height (<149, 149⩽ <152, 152⩽ <156, 156⩽), body weight at age 20 (continuous variable), alcohol drinking (ever, never), smoking (ever, never), occupation (permanent, no occupation/housewife), walking (<1 h per day, longer than 1 h per day), education level (junior high school or less, high school, college/university or higher), age at menarche (⩽13, 14, 15, 16<), age at menopause (⩽47, 48⩽ ⩽50, 51⩽ ⩽53, 54⩽), parity number (0, 1, 2, 3, 4, 5⩽), family history of breast cancer (present, absent) and history of exogenous female hormone use (ever, never).
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