Figure 1

T2 MR images from the SMO (A and B) and WT (C) mice. Arrows point to T2 hyperintensity in the cerebellum because of medulloblastoma tumours. T1-weighted MR images from mouse in panel B before (D) and 15 min after (E) i.p. injection of Magnevist. An arrow in (E) shows the signal enhancement in the tumour periphery. A T2-weighted image from the mouse in (D and E) is shown in (F). Details for MRI given under Materials and Methods section.