Table 4 CP-868,596 pharmacokinetic summary
Pharmacokinetic parameters | |||
|---|---|---|---|
Regimens | T max (h) | Cmax (ng ml–1)a | AUC(0–12) (h ng ml–1)b |
CP-868,596 (100 mg BID fed) | |||
N | 13 | 13 | 13 |
Mean | 2.30 | 493 | 3200 |
Median | 1.75 | 419 | 2240 |
CV% | 64 | 86 | 96 |
CP-868,596 (100 mg BID fed)+docetaxel (75 mg m–2) | |||
N | 13 | 13 | 13 |
Mean | 2.98 | 360 | 2540 |
Median | 3 | 326 | 1640 |
CV% | 44 | 83 | 89 |
CP-868,596 (60 mg BID fed)+axitinib (5 mg BID fed)+docetaxel (75 mg m–2) | |||
N | 5 | 5 | 5 |
Mean | 4.4 | 137 | 760 |
Median | 1.75 | 129 | 654 |
CV% | 111 | 52 | 49 |
