Figure 2 | British Journal of Cancer

Figure 2

From: MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells

Figure 2Figure 2

Transfection of pre-miR-21 into PLC/PRF/5 and HepG2. (A) qRT–PCR showed significant overexpression of miR-21 in the transfected cells compared with control cells (*P<0.05). (B) MTT assay showed that the anti-tumour effects of the combination of IFN-α and 5-FU in the miR-21 upregulated cells was significantly lower than in control cells (*P<0.05). (C and D) MTT assay revealed that the anti-tumour effects of IFN-α (C) and 5-FU (D) in the miR-21 upregulated cells was significantly less profound than in control cells (*P<0.05). (E) The percentage of early apoptotic cells induced by 1000 IU per ml IFN-α or 1.0 μg per ml 5-FU among miR-21 upregulated cells was significantly lower than in control cells (*P<0.05). Data are mean±s.d. of three experiments.

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