Table 1 Summary tablea

From: A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

  

G396D

Y179C

Genotype

Age

Sex

Ethnicity

Study

Number

GG

GA

AA

AA

AG

GG

WW

WM

MM

n (%)

Mean (SD)

n (%)

Males (%)

n (%)

Caucasian/White (%)

All studies

 Cases

20 565

19 966

324

33

20 260

154

11

19 783

417

76

20 555 (99.9)

59.5 (10.1)

20 555 (99.9)

11 668 (56.8)

5374 (26.1)

5030 (93.6)

 Controls

15 524

15 145

211

0

15 074

68

2

14 723

280

2

15 287 (98.5)

59.0 (10.9)

15 521 (99.9)

6845 (44.1)

5597 (36.1)

4796 (85.7)

Croitoru et al (2004)

 Cases

1238

1209

25

4

1223

13

2

1197

29

12

1236 (99.8)

60.1 (8.7)

1236 (99.8)

544 (44.0)

Missing

Missing

 Controls

1255

1238

17

0

1251

4

0

1234

21

0

1244 (99.1)

63.6 (8.6)

1252 (99.8)

702 (56.1)

Missing

Missing

Peterlongo et al (2005)

 Cases

585

567

3

1

569

3

0

552

4

2

584 (99.8)

62.1 (13.1)

584 (99.8)

319 (54.6)

585 (100)

251 (42.9)

 Controls

1158

1040

5

0

1039

2

0

923

7

0

1148 (99.1)

53.9 (11.5)

1156 (99.8)

240 (20.8)

1158 (100)

363 (31.3)

SOCCS (includes data from Farrington et al (2005), Tenesa et al (2006) and unpublished SOCCS prospective samples)

 Cases

3278

3086

55

8

3192

23

0

3038

71

12

3277 (100)

59.5 (11.3)

3278 (100)

1883 (57.4)

3278 (100)

3268 (99.7)

 Controls

3318

3239

43

0

3061

15

0

2993

57

0

3313 (99.8)

61.4 (10.9)

3318 (100)

1861 (56.1)

3318 (100)

3312 (99.8)

Moreno et al (2006)

 Cases

356

343

8

1

348

0

0

336

8

1

356 (100)

66.5 (11.7)

356 (100)

217 (61.0)

Missing

Missing

 Controls

297

285

7

0

291

0

0

283

7

0

297 (100)

65.3 (12.5)

297 (100)

158 (53.2)

Missing

Missing

Koessler T, (unpublished data obtained in 2007)

 Cases

2262

2215

31

2

2227

19

1

2198

37

9

2253 (99.6)

59.1 (8.1)

2262 (100)

1287 (57.1)

Missing

Missing

 Controls

2253

2217

31

0

2236

11

0

2204

42

0

2053 (91.1)

53.4 (7.6)

2253 (100)

949 (42.0)

Missing

Missing

Küry et al (2007)

 Cases

1025

1003

22

0

1021

4

0

999

25

1

1023 (99.8)

68.7 (9.9)

1025 (100)

632 (61.7)

1025 (100)

1025 (100)

 Controls

1121

1105

16

0

1117

4

0

1100

21

0

1121 (100)

61.9 (10.0)

1121 (100)

609 (54.3)

1121 (100)

1121 (100)

SOCCS retrospective cases (unpublished data obtained in 2008)

 Cases

486

403

6

2

446

2

3

391

6

4

486 (100)

54.7 (17.2)

479 (98.6)

240 (50.1)

486 (100)

486 (100)

 Controls

0

0

0

0

0

0

0

0

0

0

0

 

0

 

0

 

Cleary et al (2009)

 Cases

2076

2023

33

5

2053

7

1

2029

38

9

2070 (99.7)

56.6 (10.8)

2076 (100)

1114 (53.7)

Missing

Missing

 Controls

1049

1032

17

0

1042

6

1

1024

24

1

1047 (99.8)

56.4 (11.3)

1049 (100)

444 (42.3)

Missing

Missing

Lubbe et al (2009) b

 Cases

9268

9117

141

10

9181

83

4

9043

198

27

9268 (100)

59.0 (8.5)

9268 (100)

5432 (58.6)

Missing

Missingc

 Controls

5064

4989

75

0

5037

26

1

4962

101

1

5064 (100)

59.2 (10.8)

5064 (100)

1882 (37.2)

Missing

Missingc

  1. Abbreviations: MM=mutated/mutated; WM=wild type/mutant; WW=wild type/wild type.
  2. aThis table presents the raw data sent to us by each group that was then included in the analyses. G396D and Y179C are looked at independently and any compound bi-allelic carriers are presented as heterozygotes for each variant; MUTYH genotype data also includes other pathogenic mutations; unpublished data are included in Peterlonogo P and Moreno V, SOCCS prospective and Küry S.
  3. bIncludes data from Webb et al (2006) and Fleischmann et al (2004).
  4. cAll the cases and controls were UK residents and of European ancestry (self-reported).
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