Table 3 Meta-analysis of studies^a

	Genotype (cases)			Genotype (controls)			WM vs WW	MM vs WW
Study	WW	WM	MM	WW	WM	MM	OR (95% CI)	OR (95% CI)
Enholm et al (2003)	994	5	4	424	0	0	4.70 (0.26, 85.10)	3.84 (0.21, 71.51)
Kambara et al (2004)	90	2	0	52	—	0	1.16 (0.10, 13.06)	NA
Wang et al (2004)	432	10	2	309	4	0	1.79 (0.56, 5.75)	3.58 (0.17, 74.79)
Zhou et al (2005)	432	6	0	466	3	0	2.16 (0.54, 8.68)	NA
Peterlongo et al (2005)	549	4	2	911	7	0	0.95 (0.28, 3.25)	8.29 (0.40, 173.08)
Tomlinson I (2006)^b	662	15	1	197	2	0	2.23 (0.51, 9.84)	0.89 (0.04, 22.04)
Moreno et al (2006)	323	9	0	278	6	0	1.29 (0.45, 3.67)	NA
Colebatch et al (2006)	859	11	2	473	5	0	1.21 (0.42, 3.51)	2.75 (0.13, 57.49)
Koessler T (2007)^c	2198	37	9	2204	42	0	0.88 (0.57, 1.38)	19.05 (1.11, 327.53)
Küry et al (2007)	999	24	1	1100	21	0	1.26 (0.70, 2.27)	3.30 (0.13, 81.18)
Balaguer et al (2007)	1089	19	8	912	22	0	0.72 (0.39, 1.34)	14.24 (0.82, 247.02)
SOCCS (2008)^d	3429	77	16	2993	57	0	1.18 (0.83, 1.67)	28.80 (1.73, 480.32)
Avezzù et al (2008)	435	2	2	246	1	0	1.13 (0.10, 12.54)	2.83 (0.14, 59.19)
Cleary et al (2009) ^e	3697	87	27	2758	43	1	1.51 (1.04, 2.18)	20.14 (2.74, 148.32)
Lubbe et al (2009) ^f	9043	198	27	4962	101	1	1.08 (0.84, 1.37)	14.82 (2.01, 109.06)
M–H pooled effect (fixed)	25231	506	101	18285	315	2	1.16 (1.00, 1.34)	10.80 (5.02, 23.21)
P-value							0.05	<0.0005
Heterogeneity
P-value							0.82	0.84
I² (95% CI)							0 (0, 54)	0 (0, 60)

Abbreviations: CI=confidence interval; MM=mutated/mutated; NA=not available; OR=odds ratio; WM=wild type/mutant; WW=wild type/wild type.
^aThis table presents the data as they were published. Two unpublished studies included.
^bUnpublished data obtained in 2006.
^cUnpublished data obtained in 2007.
^dIncludes data from Farrington et al (2005), Tenesa et al (2006) and unpublished data from the SOCCS study obtained in 2008.
^eIncludes data from Croitoru et al (2004).
^fIncludes data from Webb et al (2006) and Fleischmann et al (2004).

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