Figure 1
From: LY6K is a novel molecular target in bladder cancer on basis of integrate genome-wide profiling
(A) Array-CGH profiling of five BC cell lines showing recurrence of chromosomal alterations. Integer value recurrence of copy number alterations in segmented data (y-axis) was plotted for each probe aligned along the x-axis in chromosome order. Red and green bars denote gain and loss of chromosome material, respectively. The most recurrent regions of DNA copy number gains were on chromosomes 1q, 8q, 11q, and 20q, whereas recurrent regions of copy number loss were on chromosomes 4p, 4q, 10p, 19p, and 21q. (B) Magnification of chromosome 8 locus in array-CGH profiling. Red and green denote >0.5 and <0.5 of log2 ratio value. The predominant aberration occurred at 8q24.3. (C) Smoothed copy number profile from 143.2 to 145.6 Mb on chromosome 8 (8q24.3) using CGH Analytics Software (Agilent Technologies). A total of 91 genes were located on this region, and LY6K was located at 143.8 Mb. Among the genes, 56 were upregulated more than two-fold compared with the reference RNA in the BC cell lines (Table 3).
