Figure 5
From: LY6K is a novel molecular target in bladder cancer on basis of integrate genome-wide profiling
Effects of LY6K overexpression on cell growth, migration, and invasion. (A) LY6K mRNA and protein expressions in the T24/LY6K transfectant (TF) and T24/non-targeting vector transfectant (control). The expression levels of LY6K were markedly higher in the T24/LY6K-TF than in the control. (B) Cell viability as determined by XTT assay. A significant acceleration of cell growth was observed in the T24/LY6K-TF in comparison with the control. (C) Cell migration activity by the wound healing assay. Greater acceleration of cell migration was observed in the T24/LY6K-TF than in the control. (D) Cell invasion activity by matrigel invasion assay. The number of cells invading through the membrane was significantly higher in the T24/LY6K-TF than in the control.
