Table 5 Grades 3 and 4 toxicities encountered with CAPOX in selected randomised-controlled trials
NO16968 | NO16966 | NO16967 | AIO | TTD | TREE | |
|---|---|---|---|---|---|---|
Disease setting | Adjuvant | 1st line metastatic | 2nd line metastatic | 1st line metastatic | 1st line metastatic | 1st line metastatic |
Country of origin | Global | Global | Global | Germany | Spain | USA |
Number of patients treated with CAPOX | 938 | 655 | 311 | 235 | 171 | 48 |
Grades 3 and 4 toxicities | ||||||
Diarrhoea | 20% | 20% | 19% | 15% | 14% | 31% |
Nausea and vomiting | 9% | 10% | 7% | 13% | 8% | 38% |
Stomatitis | 0.6% | 1% | <1% | 1% | 2% | NR |
Neutropenia | 9% | 6% | 5% | NR | 7% | 15% |
Hand foot syndrome | 6% | 6% | 4% | 10% | 2% | 19% |
Neurosensory | 11% | 4% | <1% | 25% | 18% | 21% |
