Table 3 Binary analysis

From: Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD

    

Univariate

Multivariate *

Cancer type

Exposed

Case

Control

OR

95%

CI

OR

95%

CI

Glioma

No

706

1317

1

  

1

  
 

Yes

67

185

0.66

0.49

0.89

0.59

0.42

0.81

Colorectal

No

5574

10 543

1

  

1

  
 

Yes

658

1467

0.85

0.77

0.94

0.84

0.75

0.94

Brain

No

505

1013

1

  

1

  

(excl glioma)

Yes

94

151

1.26

0.95

1.67

1.00

0.72

1.38

Breast

No

8651

16 834

1

  

1

  
 

Yes

1642

3262

0.98

0.92

1.05

0.97

0.91

1.04

Lung

No

5555

10 992

1

  

1

  
 

Yes

982

1522

1.30

1.19

1.42

1.14

1.02

1.28

Prostate

No

6861

13 112

1

  

1

  
 

Yes

670

1217

1.06

0.96

1.17

0.94

0.84

1.04

All

No

27 841

53 790

1

  

1

  
 

Yes

4112

7801

1.03

0.99

1.07

0.93

0.89

0.97

  1. Abbreviations: OR=odds ratio; CI=confidence interval. Patients with repeat prescriptions for tricyclics were defined as exposed. *Corrected for smoking status, diagnosis of depression, alcohol use and BMI. NSAID use corrected for in colorectal cancer only.
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