Table 1 The aberrantly expressed miRNAs and validated targets in hepatocellular carcinoma

let-7

Down

ND

c-Myc, Bcl-xL, COL1A2

Grow (−), metastasis (−)

Ji et al (2010); Lan et al (2010); Shimizu et al (2010)

miR-1

Down

Methylation

c-Met, FoxP1, HDAC4

Grow (−), metastasis (−)

Datta et al (2008)

mir-17-5p

Up

ND

ND

Grow (+), metastasis (+)

Yang et al (2010a)

miR-101

Down

ND

Mcl-1, FOS

Grow (−), apoptosis (+), metastasis (−)

Su et al (2009); Li et al (2009b)

miR-106b-25

Up

ND

p21, Bim

Grow (+), apoptosis (−)

Li et al (2009c)

miR-122

Down

HNF1A, HNF3A, HNF3B

Cyclin G1, SRF, Igf1R, Bcl-w, ADAM10, ADAM17

Grow (−), metastasis (−), apoptosis (+)

Gramantieri et al (2007); Lin et al (2008); Bai et al (2009); Coulouarn et al (2009); Fornari et al (2009); Tsai et al (2009); Zhang et al (2009a); Ma et al (2010)

miR-124

Down

Methylation

CDK6, VIM, SMYD3, IQGAP1

Grow (−), metastasis (−)^a

Furuta et al (2010)

miR-143

Up

NF-κB

FNDC3B

Metastasis (+)

Zhang et al (2009b)

miR-151

Up

Gain on 8q24.3

RhoGDIA

Metastasis (+)

Ding et al (2010)

miR-181b

Up

TGF-β

TIMP3

Metastasis (+)

Wang et al (2010)

miR-18a

Up

ND

ERα

Grow (+)

Liu et al (2009)

miR-195

Down

ND

cyclin D1, CDK6, E2F3

Grow (−)

Xu et al (2009)

miR-199a-3p

Down

ND

mTOR, c-Met

Grow (−), metastasis (−)

Fornari et al (2010)

miR-203

Down

Methylation

ABCE1

Apoptosis (+)

Furuta et al (2010)

miR-21

Up

ND

PTEN

Grow (+), metastasis (+), apoptosis (−)

Meng et al (2007)

miR-221/222

Up

c-Jun

p27, p57, DDIT4, PTEN, Bmf, TIMP3, PPP2R2A

Grow (+), metastasis (+), apoptosis (−)

le Sage et al (2007); Fornari et al (2008); Garofalo et al (2009); Gramantieri et al (2009); Pineau et al (2010); Wong et al (2010)

miR-223

Down

ND

Stathmin 1

Grow (−)

Wong et al (2008)

miR-224

Up

ND

API-5

Grow (+), apoptosis (+)

Wang et al (2008)

miR-23b

Down

ND

uPA, c-Met

Metastasis (−)

Salvi et al (2009)

miR-26a

Down

ND

Cyclin D2, Cyclin E2

Grow (−)

Kota et al (2009)

miR-29

Down

ND

Bcl-2, Mcl-1

Apoptosis (+)

Xiong et al (2010)

miR-30d

Up

ND

Gαi2

Metastasis (+)

Yao et al (2010)

miR-34a

Down

ND

c-Met

Metastasis (−)

Li et al (2009a)

miR-375

Down

ND

YAP

Grow (−), metastasis (−)

Liu et al (2010)

miR-602

Up

ND

RASSF1A

Grow (+), apoptosis (−)

Yang et al (2010b)