Table 1 Table of relationship between FKBP5 levels in cancer and drug activity of antineoplastic agents

Antineoplastic agent	Signalling pathway involved	Type of cancer	Change in FKBP51 expression	Alteration of drug susceptibility antineoplastic agent	Reference
FK506, rapamycin	PR, GR	Breast cancer	Upregulated	Resistance	Le Bihan, Marsaud et al (1998)
FK506	AR	Prostate cancer	Upregulated	Resistance	Ni et al (2010)
Dexamethasone	GR	Myeloma	Upregulated	Resistance	Rees-Unwin et al (2007)
Rapamycin	NF-κB	ALL, melanoma	Upregulated	Resistance	Romano, Avellino et al (2004); Avellino et al (2005)
Irradiation	NF-κB	Melanoma	Upregulated	Resistance	Romano et al (2010)
Gemcitabine	AKT		Downregulated
AraC	AKT		Downregulated
Epitoside	AKT	Pancreatic cancer, breast cancer	Downregulated	Resistance	Li et al (2008); Pei et al (2009)
Texane	AKT		Downregulated

Abbreviations: AKT=a serine/threonine protein kinase, also called protein kinase B; AR=androgen receptor; FKBP5= FK506 binding protein 5; GR=glucocorticoid receptor; NF-κB=nuclear factor-κB; PR=progesterone receptor.

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