Table 1 Baseline demographic and clinical characteristics of 17 patients

From: The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma

     

Thyroid autoantibody

At baseline

During sunitinib-Tx

Patient

Gender/age (year)

Pre-Tx with IFN/duration (months)

Total cycle of sunitinib

Best response by sunitinib

Thyroglobilin antibody (IU ml–1)

TPO antibody (IU ml–1)

Thyroid volume (ml)

TSH (mIu l–1)

Status

Thyroid volume (ml)

TSH (mIu l–1)

Status

 1

F/44

No

9

PR

<0.15

<0.15

18.5

5.06

Hypo

8

33.15

Hypoa

 2

F/62

No

6

PR

<0.15

<0.15

8.3

1.6

Eu

2.4

117.53

Hypoa

 3

M/65

No

23

CR

—

—

17.3

 

Unknown

1.1

137.13

Hypoa

 4

M/64

No

11

SD

—

—

10.6

9.43

Hypo

0.4

230.89

Hypoa

 5

M/69

Yes/6

10

PR

<0.15

<0.15

7.8

3.62

Eu

1.2

27.23

Hypo

 6

F/56

Yes/3

20

PR

—

—

11.6

1.86

Eu

1.7

42.53

Hypo

 7

F/59

No

18

PR

—

—

18.2

10.14

Hypo

6.6

19.8

Hypo

 8

F/66

No

16

PR

  

14.3

0.61

Eu

6.8

4.69

Hypo

 9

M/52

Yes/6

6

PR

—

—

21

1.29

Eu

22

3.06

Eu

10

F/23

No

2

PD

<0.15

<0.15

8.8

8.65

Hypo

7.9

12.72

Hypo

11

M/65

Yes/24

3

PR

<0.12

<0.05

13.6

1.66

Eu

13

3.71

Eu

12

M/55

Yes/3

2

PD

—

—

11.4

0.84

Eu

9.5

3.91

Eu

13

M/64

No

2

PD

—

—

12

1.07

Eu

10

3.93

Eu

14

M/78

Yes/6

2

SD

—

—

20.2

2.24

Eu

19.2

2.3

Eu

15

F/59

Yes/6

1

PD

<0.12

<0.05

5.8

1.49

Eu

2.8

3.14

Eu

16

M/76

Yes/20

4

SD

—

—

15.6

0.65

Eu

14

3.51

Eu

17

M/45

Yes/2

1

PD

—

—

18.9

1.57

Eu

20.9

1.73

Eu

  1. Abbreviations: CR=complete response; Eu=euthyroid; Hypo=hypothyroidism; PD=progressive disease; PR=partial response; SD=stable disease; TPO=thyroid peroxidase; TSH=thyroid stimulating hormone; Tx=treatment.
  2. aEvidence of thyrotoxicosis before experiencing hypothyroidism.