Figure 1 | British Journal of Cancer

Figure 1

From: Carbonic anhydrase IX (CA-IX) and high-risk human papillomavirus (H-HPV) as diagnostic biomarkers of cervical dysplasia/neoplasia in Japanese women with a cytologic diagnosis of atypical glandular cells (AGC): a Gynecologic Oncology Group (GOG) Study

Figure 1

The four scoring patterns of CA-IX immunoreactivity in PSs containing AGC and representative illustrations of the cases with LEGH. Patterns A and B: positive immunostaining in the atypical cells/cell clusters (A) or in the normal looking endocervical cells (B). Patterns C and D: weak positive (C) or no immunoreactivity (D) in normal cervical cells. The original low power magnification ( × 100) of patterns A, B, C and D shown in the left panels and the corresponding cell clusters marked with arrow shown in the left panel ( × 400). The case of LEGH exhibits lobular proliferation of the small glands surrounding the larger gland (original magnification × 100) with focal nuclear atypia (single arrow: benign glands, double arrow: atypia) and the area of well-differentiated adenocarcinoma (original magnification, × 400).

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