Table 2 Biomarker test (CA-IX, HPV and CA-IX+HPV) results by histological diagnosis

From: Carbonic anhydrase IX (CA-IX) and high-risk human papillomavirus (H-HPV) as diagnostic biomarkers of cervical dysplasia/neoplasia in Japanese women with a cytologic diagnosis of atypical glandular cells (AGC): a Gynecologic Oncology Group (GOG) Study

 

Histological diagnosis

Biomarker test

 

Insignificant cervical lesions

SLs

GLs

All SCLs (SLs+GLs)

Total numbera

88 (%)

51 (58)

15 (17)

22 (25)

37 (42)

CA-IX

 Negative

28 (32)

24 (47)

4 (27)

0

4 (11)

 Positive

60 (68)

27 (53)b

11 (73)

22 (100)

33 (89)

Total numberc

84 (%)

50 (59)

15 (18)

19 (23)

34 (40)

CA-IX

 Negative

47 (56)

43 (86)

4 (27)

0

4 (12)

 Positive

37 (44)

7 (14)

11 (73)

19 (100)

30 (88)

HPV (PCR)

 Negative

55 (55)

43 (51)

3 (20)

9 (47)

12 (35)

 Positive

29 (35)

7 (14)b

12 (80)

10 (53)

22 (65)

CA-IX+HPV

 Negative

22 (26)

21 (42)

1 (7)

0

1 (3)

 Positive

62 (74)

29 (58)

14 (93)

19 (100)

33 (97)

  1. Abbreviations: AIS=adenocarcinoma in situ; CA-IX=carbonic anhydrase IX; CIN=cervical intraepithelial neoplasia; GL=glandular lesion; HPV=human papillomavirus; SCL=significant cervical lesion; SL=squamous lesion.
  2. Insignificant cervical lesions, including negative/benign, CIN1, atypia and glandular hyperplasia; SLs: CIN2, CIN3 and squamous cell carcinoma; GLs: AIS and adenocarcinoma.
  3. aAll cases tested for CA-IX.
  4. bIncluding two CIN1, one atypia and one hyperplasia.
  5. cCases in which HPV (HC2) results were available.
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