Table 5 Retrospective histological evaluation with the correlation of HPV status and CA-IX expression in the Pap smears

From: Carbonic anhydrase IX (CA-IX) and high-risk human papillomavirus (H-HPV) as diagnostic biomarkers of cervical dysplasia/neoplasia in Japanese women with a cytologic diagnosis of atypical glandular cells (AGC): a Gynecologic Oncology Group (GOG) Study

Histology

Case no. ( N =84)

HPV no. of positive cases (%)

CA-IX expression no. of positive cases (%)

Negative/benign

32

4 (13)

12 (39)

Glandular hyperplasia NOS

3

0 (0)

0 (0)

Atypia

5

0 (0)

2 (40)

CIN1

6

3 (50)

5 (83)

SCLs without LEGH

 CIN 2, CIN 3

12

11(92)

10 (83)

 AIS

8

6 (75)a

8 (100)

 Adenocarcinoma

4

4 (100)

4 (100)

 Squamous cell carcinoma

1

1 (100)

1 (100)

LEGH

6

0 (0)

6 (100)

LEGH with SCLs

 CIN 2

1

0 (0)

1 (100)

 AIS

3

0 (0)

3 (100)

 Adenocarcinoma

3

0 (0)

3 (100)

  1. Abbreviations: AIS=adenocarcinoma in situ; CA-IX=carbonic anhydrase IX; CIN=cervical intraepithelial neoplasia; HPV=human papillomavirus; LEGH=lobular endocervical glandular hyperplasia; NOS=not otherwise specified; SCLs=significant cervical lesions.
  2. aTwo HPV-negative cases, in one case was also p16 negative and in the other the lesion was limited.