Summary
Anti-hepatitis C virus (HCV) antibody prevalence was investigated in 228 patients with lymphoproliferative disorders (LPDs). Twenty-six of 228 (11.40%) patients with LPDs were positive for anti-HCV which was higher than the donor population (P = 0.0007). Nine of 98 cases with non-Hodgkin’s lymphoma, five of 47 cases with multiple myeloma, seven of 36 cases with Hodgkin’s disease, four of 38 cases with chronic lymphocytic leukaemia and one of nine cases with acute lymphoblastic leukaemia had anti-HCV antibody. In all patients, odds ratio (OR) for anti-HCV was 24.09. This value was higher in patients less than 35 years as 62.04 for below 25 years and 32.00 for between 25–35 years. Our findings suggest that HCV infection might be a causative and/or contributing factor in lymphoproliferation.
Similar content being viewed by others
Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Agnello, V., Chung, R. T. & Kaplan, L. M. (1992). A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 327: 1490–1495.
Brind, A. M., Watson, J. P., Burt, A., Kesteven, P., Wallis, J., Proctor, S. J. & Bassendine, M. F. (1996). Non-Hodgkin’s lymphoma and hepatitis C virus infection. Leuk Lymphoma 21: 127–130.
Cacoub, P., Fabiani, F. L., Musset, L., Perrin, M., Franguel, L., Leger, M., Huraux, J. M., Pyette, J. C. & Godeau, P. (1994). Mixed cryoglobulinemia and hepatitis C virus. Am J Med 96: 124–132.
De Rosa, G., Gobbo, M. L., Renzo, A., Notaro, R., Garofalo, S., Grimaldi, M., Apuzzo, A., Chiurazzi, F., Picardi, M., Matarazzo, M. & Rotoli, B. (1997). High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy. Am J Hematol 55: 77–82.
Devita, S., Zagonel, V., Russo, A., Rupolo, M., Cannizzaro, R., Chiara, G., Boiocchi, M., Carbone, A. & Frenseschi, S. (1998). Hepatitis C virus, non-Hodgkin’s lymphomas and hepatocellular carcinoma. Br J Cancer 77: 2032–2035.
Ferri, C., Monti, M., La Civita, L., Longombardo, G., Greco, F., Pasero, G., Gentilini, P., Bombardieri, S. & Zignego, A. L. (1993). Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood 82: 3701–3704.
Ferri, C., Caracciolo, F., Zignego, A. L., Civita, L. L., Monti, M., Longombardo, G., Lombardini, F., Greco, F., Capochiani, E., Mazzoni, A., Mazzaro, C. & Pasero, G. (1994). Hepatitis C infection in patients with non-Hodgkin’s lymphoma. Br J Haematol 88: 392–394.
Hanley, J., Jarvis, L., Simmonds, P., Parker, A. & Ludiam, C. (1996). HCV and non-Hodgkin’s lymphoma. Lancet 347: 1339
Izumi, T., Sasaki, R., Miura, Y. & Okamoto, H. (1996). Primary hepatosplenic lymphoma: association with hepatitis C virus infection. Blood 87: 5380–5381.
Lai, R. & Weiss, R. M. (1998). Hepatitis C virus and non-Hodgkin’s lymphoma. Am J Clin Pathol 109: 508–510.
Luppi, M., Longo, G., Ferrari, M. G., Ferrara, L., Marasca, R., Barozzi, P., Morselli, M., Emilia, G. & Torelli, G. (1997). Prevalence of HCV infection and second neoplasms in marginal zone lymphomas. Br J Haematol 96: 873–874.
Mazzaro, C., Zagonel, V., Monfardini, S., Tulissi, P., Pussini, E., Fanni, M., Sorio, R., Bortolus, R., Crovatto, M., Santini, G., Tiribelli, C., Sasso, F., Masutti, R. & Pozzato, G. (1996). Hepatitis C virus and non-Hodgkin’s lymphomas. Br J Haematol 94: 544–550.
McColl, M. D. & Trait, R. C. (1996). Hepatitis C virus infection in patients with lymphoproliferative disorders. Br J Haematol 92: 771–772.
Mussini, C., Ghini, M., Mascia, M. T., Giovanardi, P., Zanni, G., Lattudo, I., Moreali, S., Longo, G., Ferrari, M. G. & Torelli, G. (1995). Monoclonal gammopathies and hepatitis C virus infection. Blood 85: 1144–1145.
Musto, P., Dell’Olio, M., Carotenuto, M., Mangia, A. & Andriulli, A. (1996). Hepatitis C virus infection: a new bridge between hematologists and gastroenterologists? Blood 88: 752–753.
Pioltelli, P., Zehender, G., Monti, G., Monteverde, A. & Galli, M. (1996). HCV and non-Hodgkin lymphoma. Lancet 347: 624–625.
Pozzato, G., Mazzaro, C., Crovatto, M., Modolo, M. L., Ceselli, S., Mazzi, G., Sulfaro, S., Franzin, F., Tulissi, P., Moretti, M. & Santini, G. F. (1994). Low grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood 84: 3047–3053.
Santini, G. F., Crovatto, M., Modolo, M. L., Martelli, P., Silvia, C., Mazzi, G., Franzin, F., Moretti, M., Tulissi, P. & Pozzato, G. (1993). Waldenstrom macroglobulinemia: a role of HCV infection. Blood 82: 2932
Sikuler, E., Shnaider, A., Zilberman, D., Hilzenrat, N., Shemer-Avni, Y., Neumann, L. & Buskila, D. (1997). Hepatitis C virus infection and extrahepatic malignancies. J Clin Gastroenterol 24: 87–89.
Silvestri, F., Pipan, C., Barillari, G., Zaja, F., Fanin, R., Infanti, L., Russo, D., Ffalasca, E., Botta, G. A. & Baccarani, M. (1996). Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders. Blood 87: 4296–4301.
Zignego, A. L., Macchia, D., Monti, M., Thiers, V., Mazzetti, M., Foschi, M., Maggi, E., Romagnoni, S., Gentilini, P. & Brechot, C. (1992). Infection of peripheral mononuclear blood cells by hepatitis C virus. J Hepatol 15: 382–386.
Zuckerman, E., Zuckerman, T., Levine, A. M., Douer, D., Gutekunst, K., Mizokami, M., Qian, D. G., Valenkar, M., Nathwani, B. N. & Fong, T. L. (1997). Hepatitis C virus infection in patients with B-cell non-Hodgkin’s lymphoma. Ann Intern Med 127: 423–428.
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Paydas, S., Kiliç, B., Sahin, B. et al. Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey. Br J Cancer 80, 1303–1305 (1999). https://doi.org/10.1038/sj.bjc.6690522
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.bjc.6690522
This article is cited by
-
Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea
Annals of Occupational and Environmental Medicine (2018)
-
Prevalence of hepatitis B and C viruses in patients with lymphoproliferative disorders
International Journal of Hematology (2008)
-
Hepatitis C virus infection in patients with essential mixed cryoglobulinemia, multiple myeloma and chronic lymphocytic leukemia
Pathology & Oncology Research (2001)
