Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

British Journal of Cancer
  • View all journals
  • Search
  • My Account Login
  • Content Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • RSS feed
  1. nature
  2. british journal of cancer
  3. editorials
  4. article
Of (only) mice and men
Download PDF
Download PDF
  • Editorial
  • Open access
  • Published: 15 October 1999

Of (only) mice and men

  • B Leyland-Jones1 &
  • C K Grieshaber2 

British Journal of Cancer volume 81, pages 753–755 (1999)Cite this article

  • 828 Accesses

  • 2 Citations

  • Metrics details

This article has been updated

Article PDF

Change history

  • 16 November 2011

    This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

References

  • Arbuck, SG (1996) Workshop on phase I study design. Ann Oncol 7: 567–573.

    Article  CAS  Google Scholar 

  • Collins, JM, Zaharko, DS, Dedrick, RL & Chabner, BA (1986) Potential roles for preclinical pharmacology in phase I clinical trials. Cancer Treat Rep 70: 73–80.

    CAS  PubMed  Google Scholar 

  • Collins, JM, Grieshaber, CK & Chabner, BA (1990) Pharmacologically guided phase I clinical trials based upon preclinical drug development. J Natl Cancer Inst 82: 1321–1326.

    Article  CAS  Google Scholar 

  • DeGeorge, JJ, Ahn, C-H, Andrews, PA, Brower, ME, Giorgio, DW, Goheer, ME, Lee-Ham, DY, McGuinn, WD, Schmidt, W, Sun, CJ & Tripathi, SC (1998) Regulatory considerations for preclinical development of anticancer drugs. Cancer Chemother Pharmacol 41: 173–185.

    Article  CAS  Google Scholar 

  • Dent, SF & Eisenhauer, EA (1996) Phase I trial design: are new methodologies being put into practice?. Ann Oncol 7: 561–566.

    Article  CAS  Google Scholar 

  • Fox, BW (1998) The history of radium in medicine in Manchester. Clin Oncol 10: 115–124.

    Article  CAS  Google Scholar 

  • Freireich, EJ, Gehan, EA, Rall, DP, Schmidt, LH & Skipper, HE (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 50: 219–244.

    CAS  PubMed  Google Scholar 

  • Goldsmith, MA, Slavik, M & Carter, SK (1975) Quantitative prediction of drug toxicity in humans from toxicology in small and large animals. Cancer Res 35: 1354–1364.

    CAS  PubMed  Google Scholar 

  • Grieshaber, CK & Marsoni, S (1986) Relationship of preclinical toxicology to finding in early clinical trials. Cancer Treat Rep 70: 65–72.

    CAS  PubMed  Google Scholar 

  • Homan, ER (1972) Quantitative relationships between toxic doses of antitumour chemotherapeutic agents in animals and man. Cancer Chemother Rep Part 3: 13–19.

    CAS  Google Scholar 

  • Penta, JS, Rozencweig, M, Guarino, AM & Muggia, FM (1979) Mouse and large-animal toxicology studies of twelve antitumour agents: relevance to starting dose for phase I clinical trials. Cancer Chemother Pharmacol 3: 97–101.

    Article  CAS  Google Scholar 

  • Penta, JS, Rosner, GL & Trump, DL (1992) Choice of starting dose and escalation for phase I studies of antitumour agents. Cancer Chemother Pharmacol 31: 247–250.

    Article  CAS  Google Scholar 

  • Ratain, MJ, Mick, R, Schilsky, RL & Siegler, M (1993) Statistical and ethical issues in the design and conduct of phase I and phase II clinical trials of new anticancer agents. J Natl Cancer Inst 85: 1637–1643.

    Article  CAS  Google Scholar 

  • Rozencweig, M, VonHoff, DD, Staquet, MJ, Schein, PS, Penta, JS, Goldin, A, Muggia, FM, Freireich, EJ & DeVite, VT (1981) Animal toxicology for early clinical trials with anticancer agents. Cancer Clin Trials 4: 21–28.

    CAS  PubMed  Google Scholar 

  • Simon, R, Freidlin, B, Rubinstein, L, Arbuck, S, Collins, J & Christain, MC (1997) Accelerated titration designs for phase I clinical trials in oncology. J Natl Cancer Inst 89: 1138–1147.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, McGill University, Montreal, Quebec, Canada

    B Leyland-Jones

  2. Drug Discovery and Development, Karmanos Cancer Institute, Detroit, MI, USA

    C K Grieshaber

Authors
  1. B Leyland-Jones
    View author publications

    Search author on:PubMed Google Scholar

  2. C K Grieshaber
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to B Leyland-Jones.

Rights and permissions

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

Reprints and permissions

About this article

Cite this article

Leyland-Jones, B., Grieshaber, C. Of (only) mice and men. Br J Cancer 81, 753–755 (1999). https://doi.org/10.1038/sj.bjc.6690759

Download citation

  • Received: 22 April 1999

  • Accepted: 23 April 1999

  • Published: 15 October 1999

  • Issue date: 01 November 1999

  • DOI: https://doi.org/10.1038/sj.bjc.6690759

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Download PDF

Advertisement

Explore content

  • Research articles
  • Reviews & Analysis
  • News & Comment
  • Current issue
  • Collections
  • Follow us on X
  • Sign up for alerts
  • RSS feed

About the journal

  • Journal Information
  • Open access publishing
  • About the Editors
  • Contact
  • Special Issues
  • For Advertisers
  • Subscribe

Publish with us

  • For Authors & Referees
  • Language editing services
  • Open access funding
  • Submit manuscript

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

British Journal of Cancer (Br J Cancer)

ISSN 1532-1827 (online)

ISSN 0007-0920 (print)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • protocols.io
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Professional development

  • Nature Awards
  • Nature Careers
  • Nature Conferences

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Japan
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • Your US state privacy rights
Springer Nature

© 2026 Springer Nature Limited