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Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer
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  • Regular Article
  • Open access
  • Published: 17 December 1999

Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer

  • T Kato1,
  • T Kimura1,
  • R Miyakawa1,
  • A Fujii1,
  • K Yamamoto1,
  • S Kameoka1,
  • T Nishikawa2 &
  • …
  • T Kasajima3 

British Journal of Cancer volume 82, pages 404–411 (2000)Cite this article

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Abstract

This study was undertaken to determine the absolute and relative value of blood vessel invasion (BVI) using both factor VIII-related antigen and elastica van Gieson staining, proliferating cell nuclear antigen (PCNA), p53, c- erb B-2, and conventional prognostic factors in predicting relapse-free survival (RFS) and overall survival (OS) rates associated with long-term survival in Japanese patients with node-negative breast cancer. Two hundred patients with histological node-negative breast cancer were studied. We investigated nine clinicopathological factors, including PCNA, p53, c- erb B-2 using permanent-section immunohistochemistry, clinical tumour size (T), histological grade (HG), mitotic index (MI), tumour necrosis (TN), lymphatic vessel invasion (LVI) and BVI, followed for a median of 10 years (range 1–20). Twenty-one patients (10.5%) had recurrence and 15 patients (7.5%) died of breast cancer. Univariate analysis showed that BVI, PCNA, T, HG, MI, p53, c- erb B-2 and LVI were significantly predictive of 20-year RFS or OS. Multivariate analysis showed that BVI (P = 0.0159, P = 0.0368), proliferating cell nuclear antigen (PCNA) (P = 0.0165, P = 0.0001), and T (P = 0.0190, P = 0.0399) were significantly independent prognostic factors for RFS or OS respectively. BVI, PCNA and T were independent prognostic indicators for RFS or OS in Japanese patients with node-negative breast cancer and are useful in selecting high-risk patients who may be eligible to receive strong adjuvant therapies. © 2000 Cancer Research Campaign

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  • 16 November 2011

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Authors and Affiliations

  1. Department of Surgery II, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    T Kato, T Kimura, R Miyakawa, A Fujii, K Yamamoto & S Kameoka

  2. Department of Surgical Pathology, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    T Nishikawa

  3. Department of Pathology, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    T Kasajima

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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Kato, T., Kimura, T., Miyakawa, R. et al. Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer. Br J Cancer 82, 404–411 (2000). https://doi.org/10.1054/bjoc.1999.0934

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  • Received: 07 August 1998

  • Revised: 14 July 1999

  • Accepted: 15 July 1999

  • Published: 17 December 1999

  • Issue date: 01 January 2000

  • DOI: https://doi.org/10.1054/bjoc.1999.0934

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Keywords

  • blood vessel invasion
  • clinical tumour size
  • long-term survival
  • node-negative breast cancer
  • proliferating cell nuclear antigen (PCNA)

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