Abstract
The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC Msh2Δ7N. Chromosome aberration frequencies were similar in bone marrow of Msh2+/+ Msh2+/– and Msh2–/– mice and no differential effects of in vivo X-irradiation were noted. By contrast, the induction of sister-chromatid exchanges (SCEs) by methyl nitrosourea (MNU) was reduced in Msh2–/– and Msh2+/– cells to ~20% and ~45% wild-type levels respectively indicating a phenotypic effect of haploinsufficiency of the mouse Msh2 gene. © 2000 Cancer Research Campaign
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Bouffler, S., Hofland, N., Cox, R. et al. Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis. Br J Cancer 83, 1291–1294 (2000). https://doi.org/10.1054/bjoc.2000.1422
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DOI: https://doi.org/10.1054/bjoc.2000.1422
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