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Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers
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  • Published: 27 February 2001

Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers

  • E Kerkelä1,
  • R Ala-aho2,5,
  • L Jeskanen,
  • J Lohi6,
  • R Grénman3,
  • V M-Kähäri4,5 &
  • …
  • U Saarialho-Kere1 

British Journal of Cancer volume 84, pages 659–669 (2001)Cite this article

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Abstract

Co-expression of several members of the matrix metalloproteinase (MMP) family is characteristic of human malignant tumours. To investigate the role of stromelysin-2 (MMP-10) in growth and invasion of skin tumours, we studied cutaneous carcinomas with high metastatic capacity (squamous cell carcinomas, SCCs), only locally destructive tumours (basal cell carcinomas, BCCs) and pre-malignant lesions (Bowen’s disease and actinic keratosis) using in situ hybridization. Expression of MMP-10 was compared with that of stromelysin-1 (MMP-3) and of MT1-MMP, the expression of which has been shown to correlate with tumour invasiveness. MMP-10 was expressed in 13/21 SSCs and 11/19 BCCs only in epithelial laminin-5 positive cancer cells, while premalignant lesions were entirely negative. MT1-MMP mRNA was detected in 19/21 SCCs both in epithelial cancer cells and stromal fibroblasts and in 14/18 BCCs only in fibroblasts. The level of MMP-10 was upregulated in a cutaneous SCC cell line (UT-SCC-7) by transforming growth factor-α and keratinocyte growth factor, and by interferon-γ in combination with transforming growth factor-β1 and tumour necrosis factor-α both in UT-SCC-7 and HaCaT cells. Our results show that MMP-10 expression does not correlate with the invasive behaviour of tumours as assessed by their histology and MT1-MMP expression, but may be induced by the wound healing and inflammatory matrix remodelling events associated with skin tumours. © 2001 Cancer Research Campaign

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  • 16 November 2011

    This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

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Authors and Affiliations

  1. Department of Dermatology, Helsinki University Central Hospital, Helsinki

    E Kerkelä & U Saarialho-Kere

  2. Department of Dermatology, Turku University Central Hospital, Turku, Finland

    R Ala-aho

  3. Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Central Hospital, Turku, Finland

    R Grénman

  4. Department of Medical Biochemistry and MediCity Research Laboratory, University of Turku, Turku, Finland

    V M-Kähäri

  5. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

    R Ala-aho & V M-Kähäri

  6. Department of Pathology, Haartman Institute, University of Helsinki, Finland

    J Lohi

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  1. E Kerkelä
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  2. R Ala-aho
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  3. L Jeskanen
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Kerkelä, E., Ala-aho, R., Jeskanen, L. et al. Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. Br J Cancer 84, 659–669 (2001). https://doi.org/10.1054/bjoc.2000.1634

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  • Received: 12 June 2000

  • Revised: 03 October 2000

  • Accepted: 18 October 2000

  • Published: 27 February 2001

  • Issue date: 02 March 2001

  • DOI: https://doi.org/10.1054/bjoc.2000.1634

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Keywords

  • laminin-5
  • stromelysin-1
  • cytokine

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