Abstract
Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml–1) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign
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Berge, D., Ridder, M., Verovski, V. et al. Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase. Br J Cancer 84, 1122–1125 (2001). https://doi.org/10.1054/bjoc.2000.1719
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DOI: https://doi.org/10.1054/bjoc.2000.1719
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