Abstract
Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
Bruera E (1997) Anorexia, cachexia, and nutrition. BMJ 315: 1219–1222
Choudhary G, Chakel J, Hancock W, Torres-Duarte A, McMahon G and Wainer IW (1999) Investigation of the potential of capillary electrophoresis (CE) with off-line matrix assisted laser desorption/ionization time of flight (MALDITOF) mass spectrometry for clinical analysis: examination of a glycoprotein factor associated with cancer cachexia. Anal Chem 71: 855–859
Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, Cohen MH, Douglass HO Jr, Engstrom PF, Ezdinli EZ, Horton J, Johnson GJ, Moertel CG, Oken MM, Perlia C, Rosenbaum C, Silverstein MN, Skeel RT, Sponzo RW and Tormey DC (1980) Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69: 491–497
Gullu I and Marangoz S (1999) Induction of cachexia in mice (letter). Br J cancer 79: 1620
Tisdale M (1999) Induction of cachexia in mice-reply (letter). Br J Cancer 79: 1620
Todorov P, Cariuk P, McDevitt T, Coles B, Fearon K and Tisdale M (1996a) Characterization of a cancer cachetic factor. Nature 379: 739–742
Todorov PT, McDevitt TM, Cariuk P, Coles B, Deacon M and Tisdale MJ (1996b) Induction of muscle protein degradation and weight loss by a tumour product. Cancer Res 56: 1256–1261
Wigmore SJ, Todorov PT, Barber MD, Ross JA, Tisdale MJ and Fearon KC (2000) Characteristics of patients with pancreatic cancer expressing a novel cancer cachectic factor. Br J Surg 87: 53–58
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Cabal-Manzano, R., Bhargava, P., Torres-Duarte, A. et al. Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. Br J Cancer 84, 1599–1601 (2001). https://doi.org/10.1054/bjoc.2001.1830
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DOI: https://doi.org/10.1054/bjoc.2001.1830
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