Abstract
We have established the first example of an orthotopic xenograft model of human nonseminomatous germ cell tumour (NSGCT). This reproducible model exhibits many clinically relevant features including metastases to the retroperitoneal lymph nodes and lungs, making it an ideal tool for research into the development and progression of testicular germ cell tumours. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
An Z, Jiang P, Wang X, Moossa AR and Hoffman RM (1999) Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: benefits of fragment implantation compared to cell-suspension injection. Clin Exp Metastasis 17: 265–270
Benedetto P (1999) Chemotherapy of Testis Cancer. Cancer Control 6: 549–559
Bergstrom R, Adami HO, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O and Hakulinen T (1996) Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88: 727–733
Fidler IJ (1990) Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 50: 6130–6138
Fogh J, Wright WC and Loveless JD (1977) Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst 58: 209–214
Hii SI, Nicol DL, Gotley DC, Thompson LC, Green MK and Jonsson JR (1998) Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma. Br J Cancer 77: 880–883
Hoffman RM (1999) Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 17: 343–359
Looijenga LH and Oosterhuis JW (1999) Pathogenesis of testicular germ cell tumours. Rev Reprod 4: 90–100
Pera MF, Blasco Lafita MJ and Mills J (1987) Cultured stem-cells from human testicular teratomas: the nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma. Int J Cancer 40: 334–343
Thompson S, Stern PL, Webb M, Walsh FS, Engstrom W, Evans EP, Shi WK, Hopkins B and Graham CF (1984) Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid. J Cell Sci 72: 37–64
Toner GC and Motzer RJ (1998) Poor prognosis germ cell tumors: current status and future directions. Semin Oncol 25: 194–202
Walt H, Oosterhuis JW and Stevens LC (1993) Experimental testicular germ cell tumorigenesis in mouse strains with and without spontaneous tumours differs from development of germ cell tumours of the adult human testis. Int J Androl 16: 267–271
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Douglas, M., Boucaut, K., Antalis, T. et al. An orthotopic xenograft model of human nonseminomatous germ cell tumour. Br J Cancer 85, 608–611 (2001). https://doi.org/10.1054/bjoc.2001.1884
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DOI: https://doi.org/10.1054/bjoc.2001.1884
