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Haemophilus influenzae type b serology in childhood leukaemia: A case–control study
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  • Short Communication
  • Open access
  • Published: 31 July 2001

Haemophilus influenzae type b serology in childhood leukaemia: A case–control study

  • F D Groves1,2,
  • D Sinha1,
  • H Kayhty3,
  • J J Goedert4 &
  • …
  • P H Levine4 

British Journal of Cancer volume 85, pages 337–340 (2001)Cite this article

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Abstract

Antibody to Haemophilus influenzae type b (Hib) polysaccharide (PRP) was measured in 42 children with acute lymphoblastic leukaemia (ALL) and 42 non-leukaemic hospital controls. Modelling anti-PRP concentrations as a function of age revealed that the slopes of the trend lines differed significantly between cases and controls (P = 0.05); anti-PRP concentrations were lower among younger cases, and higher among older cases, than among controls of the same ages. © 2001 Cancer Research Campaign

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Change history

  • 16 November 2011

    This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

References

  • Auvinen A, Hakulinen T and Groves FD (2000) Haemophilus influenzae type b vaccination and risk of childhood leukaemia in a vaccine trial in Finland. Br J Cancer 83: 956–958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eskola J, Käyhty H, Takala AK, Peltola H, Rönnberg P-R and Kela E (1990) A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. N Engl J Med 323: 1381–1387

    Article  CAS  PubMed  Google Scholar 

  • Feldman S, Gigliotti F, Shenep JL, Roberson PK and Lott L (1990) Risk of Haemophilus influenzae type b disease in children with cancer and response of immunocompromised leukemic children to a conjugate vaccine. J Infect Dis 161: 926–931

    Article  CAS  PubMed  Google Scholar 

  • Greaves M (1993) A natural history for paediatric acute leukaemia. Blood 82: 1043–1051

    CAS  PubMed  Google Scholar 

  • Greaves MF (1997) Aetiology of acute leukaemia. Lancet 349: 344–349

    Article  CAS  PubMed  Google Scholar 

  • Greaves MF (1999) Molecular genetics, natural history, and the demise of childhood leukaemia. Eur J Cancer 35: 173–185

    Article  CAS  PubMed  Google Scholar 

  • Groves FD, Gridley G, Wacholder S, Shu X-O, Robison LL, Neglia J and Linet MS (1999) Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the United States. Br J Cancer 81: 175–178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Käyhty H, Eskola J, Peltola H, Stout M, Samuelson JS and Gordon LK (1987) Immunogenicity in infants of a vaccine composed of Haemophilus influenzae type b capsular polysaccharide mixed with DPT or conjugated to diphtheria toxoid. J Infect Dis 155: 100–106

    Article  PubMed  Google Scholar 

  • Phipps DC, West J, Eby R, Koster M, Madore DV and Quataert SA (1990) An ELISA employing a Haemophilus influenzae type b oligosaccharide-human serum albumin conjugate correlates with the radioantigen binding assay. J Immunol Methods 135: 121–128

    Article  CAS  PubMed  Google Scholar 

  • Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A and Greaves MF (1999). Lancet 354: 1499–1503

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Author information

Authors and Affiliations

  1. Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA

    F D Groves & D Sinha

  2. Biostatistics Branch, National Cancer Institute, Rockville, Maryland, USA

    F D Groves

  3. Laboratory of Vaccine Immunology, National Public Health Institute, Helsinki, Finland

    H Kayhty

  4. Viral Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA

    J J Goedert & P H Levine

Authors
  1. F D Groves
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  2. D Sinha
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  3. H Kayhty
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  4. J J Goedert
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  5. P H Levine
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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Cite this article

Groves, F., Sinha, D., Kayhty, H. et al. Haemophilus influenzae type b serology in childhood leukaemia: A case–control study. Br J Cancer 85, 337–340 (2001). https://doi.org/10.1054/bjoc.2001.1903

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  • Received: 28 February 2001

  • Revised: 24 April 2001

  • Accepted: 25 April 2001

  • Published: 31 July 2001

  • Issue date: 03 August 2001

  • DOI: https://doi.org/10.1054/bjoc.2001.1903

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Keywords

  • leukaemia
  • child
  • serology
  • Haemophilus influenzae type b
  • case–control study

This article is cited by

  • Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

    • Srividya Swaminathan
    • Lars Klemm
    • Markus Müschen

    Nature Immunology (2015)

  • Infection, immune responses and the aetiology of childhood leukaemia

    • Mel Greaves

    Nature Reviews Cancer (2006)

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