Table 1 Known heterochromatic genes and gene models on chromosome 2 and their functions
Scaffold (kb) | CG (alleles) | D. melanogaster molecular function (GO) | Closest BLASTx human hit (P(n)) | |
|---|---|---|---|---|
AABU1002768 (594) | CG17540 (1) | Pre-mRNA splicing factor | NP_116294.1, RNA-binding motif protein 17 (1e-55) | |
CG41117 (1) | Unknown | No significant similarity found | ||
Cht3 (1) | Chitin binding, chitinase | AAG60019.1, acidic mammalian chitinase precursor (8e-75) | ||
concertina (14) | GTPase; GTP binding; signal transducer | NP_006563.2, guanine nucleotide-binding protein alpha 13 (6e-100) | ||
CR40471 | Misc. RNAs | |||
CG40005 (1) | GTPase | AAA74235.1, guanine nucleotide regulatory protein (7e-23) | ||
light (47) | Ubiquitin-protein ligase; zinc ion binding | P49754, vacuolar assembly protein VPS41 homologue (S53) (3e-147) | ||
CG41118 (1) | Unknown | No significant similarity found | ||
CG17715 (1) | Unknown | AAH32396.1, LOC157378 protein (4e-29) | ||
CG41121 (1) | Unknown | No significant similarity found | ||
CG40439 (1) | Unknown | No significant similarity found | ||
CG41119 (1) | Unknown | No significant similarity found | ||
CG41120 (1) | Unknown | No significant similarity found | ||
CG40006 (1) | Serine-type endopeptidase inhibitor; receptor | AAH80647.1, scavenger receptor class B member 1 (2e-48) | ||
CG17494 (1) | Unknown | NP_009090.2, sarcolemma-associated protein (1e-61) | ||
CG17493 (1) | Calmodulin binding; calcium ion binding | AAP35920.1, centrin EF hand protein 2 (7e-62) | ||
CG17490 (1) | Unknown | No significant similarity found | ||
RpL5 (5) | Ribosomal protein L5 | NP_000960.2, ribosomal protein L5 (4e-119) | ||
AABU01002756 (199) | CG12567 (1) | Thiamine diphosphokinase | No significant similarity found | |
CG40040 (1) | Unknown | No significant similarity found | ||
CG40041 (1) | Hormone | AA033390.1, glycoprotein hormone beta subunit (2e-10) | ||
CG40042 (1) | Carrier; protein transporter | AAR14723.1, mitochondrial inner membrane translocase 23 (8e-36) | ||
AABU01002199 (160) | CG40211 (1) | Unknown | No significant similarity found | |
CG40212 (1) | Unknown | No significant similarity found | ||
CG40216 (1) | Unknown | No significant similarity found | ||
CG40218 (2) | Kinesin binding | AAP88821.1, craniofacial development protein 1 (2e-20) | ||
CG40334 (1) | Nucleic acid binding; damaged DNA binding | XP_371082.1, PREDICTED: hypothetical protein FLJ20753 (6e-19) | ||
CG40220 (1) | Unknown | No significant similarity found | ||
CG40214 (1) | Nucleic acid binding; damaged DNA binding | XP_371082.1, PREDICTED: hypothetical protein FLJ20753 (4e-29) | ||
AABU01001947 (252) | CG40241 (1) | Unknown | No significant similarity found | |
CG12552 (1) | Unknown | No significant similarity found | ||
CG40498 (1) | Unknown | No significant similarity found | ||
CG40239 (1) | Unknown | No significant similarity found | ||
rolled (90) | MAP kinase | AAH17832.1, mitogen-activated protein kinase 1 (2e-168) | ||
CG40244 (1) | Unknown | CAA77753.1, 40 kDa protein kinase (5e-05) | ||
AABU01002549 (120) | CG41063 (1) | Unknown | No significant similarity found | |
CG40190 (1) | Protein kinase | NP_002737.1, mitogen-activated protein kinase 3 (6e-45) | ||
CG41066 (1) | Unknown | No significant similarity found | ||
CG40192 (1) | Unknown | No significant similarity found | ||
CG41065 (1) | Unknown | No significant similarity found | ||
CG40191 (1) | Unknown | AAD34052.1, CGI-57 protein (2e-20) | ||
AABU01002750 (143) | CG17691 (1) | 3 methyl-2-oxobutanoate dehydrogenase | CAI15049.1, branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) (1e-135) | |
CG40068 (1) | Nucleic acid binding; translation factor | AAM14617.1, mitochondrial translation-initiation factor 2 (4e-32) | ||
CG40388 (1) | Unknown | No significant similarity found | ||
CG40390 (1) | Unknown | CAI12944.1, KARP-1-binding protein (KAB) (0.005) | ||
CG40067 (1) | Unknown | No significant similarity found | ||
AABU01002748 (134) | CG40084 (1) | Unknown | NP_951058.1, cyclin M2 isoform 2 (4e-117) | |
CG40081 (1) | Unknown | No significant similarity found | ||
CG40080 (1) | ATP binding; protein serine/threonine kinase | NP_114171.2, serine/threonine protein kinase Haspin (3e-69) | ||
CG40085 (1) | Unknown | No significant similarity found | ||
CG41098 (1) | Unknown | No significant similarity found | ||
AABU01002711 (342) | CG40130 (1) | Unknown | No significant similarity found | |
CG40129 (1) | ATP binding; G-protein-coupled receptor kinase | NP_005151.1, beta adrenergic receptor kinase 2 (0.0) | ||
CG17665 (2) | Unknown | NP_075391.3, hypothetical protein LOC65123 (0.0) | ||
CG40131 (1) | Unknown | No significant similarity found | ||
CG40127 (1) | Unknown | NP_001004333.1, hypothetical protein LOC440400 (1e-11) | ||
CG40128 (1) | Unknown | No significant similarity found | ||
CG40133 (1) | Unknown | No significant similarity found | ||
CG17683 (1) | Oxidoreductase; ferredoxin hydrogenase | NP_071938.1, nuclear prelamin A recognition factor-like (5e-113) | ||
AABU01002740 (252) | CG17514 (1) | Translation activator; kinase regulator | NP_006827.1, GCN1 general control of amino-acid synthesis 1-like 1 (0.0) | |
CG40103 (1) | Unknown | No significant similarity found | ||
CG40163 (1) | Unknown | No significant similarity found | ||
CG10837 (eIF-4B) (8) | RNA binding; translation initiation factor | AAH73154.1, eukaryotic translation initiation factor 4B (6e-32) | ||
CG40105 (1) | Specific RNA pol II transcription factor | NP_002136.1, homeo box B2 (1e-09) | ||
AABU01002769 (2465) | RpL38 (6) | Ribosomal protein 38 | NP_000990.1, ribosomal protein L38 (1e-24) | |
CG40293 (1) | ATP binding; protein serine/threonine kinase | DAA01797.1, TPA: STE20-related adaptor protein (1e-41) | ||
AAG48269.1, breast cancer antigen NY-BR-96 (1e-41) | ||||
CG40290 (1) | Unknown | No significant similarity found | ||
p120ctn (12) | Adherens junction protein | AAB97957.1, arm-repeat protein NPRAP/neurojungin (2e-131) | ||
CG17486 (1) | Ligase; asparagine synthase | NP_061921.1, hypothetical protein LOC54529 (8e-73) | ||
CG17478 (1) | Unknown | No significant similarity found | ||
CG17883 (1) | Unknown | NP_653229.1, TBC1 domain family, member 20 (1e-66) | ||
Nipped-B (8) | Transcriptional activator; sister chromatid cohesion | NP_597677.2, delangin isoform A (SCC2 homologue) (0.0) | ||
CG17706 (2) | Unknown | No significant similarity found | ||
CG17082 (1) | Unknown | NP_277050.2, Rho GTPase activating protein 18 (7e-23) | ||
CG12547 (1) | Unknown | CAH73013.1, novel NHL repeat domain-containing protein (8e-127) | ||
CG17528 (1) | Microtubule binding; ATP binding; protein serine/threonine kinase | NP_004725.1, doublecortin and CaM kinase-like 1 (5e-131) | ||
CG40285 (1) | Unknown | NP_689529.1, hypothetical protein LOC120534 (1e-15) | ||
AE003788 (585) | CR30260 | TRNA | — | |
CR30505 | TRNA | — | ||
CG33492 (1) | Ionotropic glutamate receptor | CAH73378.1, glutamate receptor, ionotropic, delta 1 (5e-08) | ||
TpnC41C (1) | Calcium ion binding | AAH08437.1, Calmodulin 2 (1e-33) | ||
AE003787 (294) | CG3107 (1) | Metalloendopeptidase | NP_055704.2, metalloprotease 1 (0.0) | |
gustavus (4) | Oocyte anterior/posterior axis determination | BAD92796.1, SPRY domain-containing SOCS box protein SSB-1 variant (3e-115) | ||
CG3136 (2) | DNA binding; protein homodimerization | BAA34722.1, cAMP-dependent transcription factor ATF-6 beta (4e-18) | ||
Nipped-A (47) | Transcription regulator; receptor signalling | NP_003487.1, TRRAP protein (0.0) | ||
d4 (1) | Transcription factor; ubiquitin-protein ligase | AAP35364.1, requiem, apoptosis response zinc-finger gene (1e-51) | ||
Ogt (1) | Transferase activity, transferring glycosyl groups | NP_858059.1, O-linked GlcNAc transferase, isoform 2 (0.0) | ||
CG10465 (2) | Voltage-gated potassium channel; protein binding | NP_114160.1, potassium channel tetramerization domain containing 10 (1e-100) | ||
CG10395 (1) | HIT Zn-finger protein domain | NP_112578.1, high mobility group AT-hook 1-like 4 (4e-20) | ||
CG30441 (1) | Unknown | AAP50265.1, intraflagellar transport protein 20-like protein (8e-16) | ||
CG10396 (1) | Cytochrome c oxidase | P13073, Cytochrome c oxidase polypeptide IV (7e-24) | ||
CG33347 (1) | Unknown | No significant similarity found | ||
CG10417 (1) | Protein serine/threonine phosphatase | 015355, protein phosphatase 2C gamma isoform (8e-67) | ||
AE003786 (280) | CG30437 (2) | Laccase; copper ion binding | AAQ24260.1, MY 01 protein (0.001) | |
CG32838 (1) | Another laccase; 75% identical to CG30437 | AAQ24260.1, MY 01 protein (5e-04) | ||
CG30440 (1) | Guanyl-nucleotide exchange factor | AAA52172.1, DBL transforming protein (1e-74) | ||
CG30438 (1) | Transferase activity, transferring glycosyl groups | AAC51187.1, ceramide UDPgalactosyltransferase (2e-61) | ||
TpnC4 (1) | Calcium ion binding | AAH08437.1, Calmodulin 2 (7e-25) | ||
CG17510 (1) | Unknown | Q9Y3D6, tetratricopeptide repeat protein 11 (Fis 1 homologue) (1e-16) | ||
CG17508 (1) | Unknown | NP_543011.1, hypothetical protein LOC116151 (1e-23) | ||
CG11665 (1) | Monocarboxylic acid transporter | NP_963860.1, monocarboxylate transporter 13 (7e-36) | ||
