ABSTRACT
Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.
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GAO, C., WOUDE, G. HGF/SF-Met signaling in tumor progression. Cell Res 15, 49–51 (2005). https://doi.org/10.1038/sj.cr.7290264
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DOI: https://doi.org/10.1038/sj.cr.7290264
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