ABSTRACT
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFs often exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemical mechanisms of action of the two KLFs in the context of growth regulation.
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Abbreviations
- BTE:
-
basic transcription element
- BTEB2:
-
basic transcription element binding protein 2
- CYP1A1:
-
cytochrome P-450IA1
- KLF:
-
Krüppel-like factor
- MAPK:
-
mitogen-activated protein kinase
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Acknowledgements
This work was in part supported by grants from the National Institutes of Health (DK52230, DK64399 and CA84197). Vincent W.Yang is the recipient of a Georgia Cancer Coalition Distinguished Cancer Clinician Scientist Award. W. Brian. Dalton is a member of the Medical Scientist Training Program of Emory University School of Medicine.
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GHALEB, A., NANDAN, M., CHANCHEVALAP, S. et al. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res 15, 92–96 (2005). https://doi.org/10.1038/sj.cr.7290271
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DOI: https://doi.org/10.1038/sj.cr.7290271
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