Abstract
RNase MRP RNA is the RNA subunit of the RNase mitochondrial RNA processing (MRP) enzyme complex that is involved in multiple cellular RNA processing events. Mutations on RNase MRP RNA gene (RMRP) cause a recessively inherited developmental disorder, cartilage-hair hypoplasia (CHH). The relationship of the genotype (RMRP mutation), RNA processing deficiency of the RNase MRP complex, and the phenotype of CHH and other skeletal dysplasias is yet to be explored.
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Acknowledgements
Research on RNase MRP in Li Y's laboratory is supported by a pilot study grant for Systems Biology from the Center for Genetics and Molecular Medicine, University of Louisville. Li Y is supported by a Beginning-Grant-In-Aid grant from the American Heart Association. Li Y is grateful to fantastic colleagues Drs Mark D Brennan, Marlene C Steffen, and Yanglong Zhu for critical reading of the manuscript.
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Martin, A., Li, Y. RNase MRP RNA and human genetic diseases. Cell Res 17, 219–226 (2007). https://doi.org/10.1038/sj.cr.7310120
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DOI: https://doi.org/10.1038/sj.cr.7310120
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