Abstract
We report here on the chromosomal mapping of the adrenoleukodystrophy-related (ALDR) gene on both the human and the mouse genomes. This gene encodes a peroxisomal ATP binding cassette transporter, closely related to the transporter identified as responsible for the adrenoleukodystrophy phenotype. ALDR maps on the syntenic region on murine and human autosomes. In addition, we could determine its position in relation to known microsatellite framework markers; this will allow to test its role in Zellweger syndrome and/or related peroxisomal disorders.
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References
Moser HW, Moser A: Adrenoleukodystrophy (X linked); in Scriver C, Beaudet A, Sly W, Valle D (eds): The Metabolic Basis of Inherited Diseases. New York, McGraw-Hill, pp 1511–1532, 1989.
Moser HW: Clinical and therapeutic aspects of adrenoleukodystrophy and adrenomyeloneuropathy. J Neuropathol Exp Neurol 1995;54: 740–745.
Mosser J, Douar AM, Sarde CO, Kioschis P, Feil R, Moser H, Poustka AM, Mandel JL, Aubourg P: Nature 1993;361:726–730.
Higgins CF: ABC transporters from microorganisms to man. Annu Rev Cell Biol 1992;8: 67–113.
Valle D, Gartner J: Penetrating the peroxisome. Nature 1993;361:682–683.
Gartner J, Moser H, Valle D: Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome. Nature Genet 1992; 1:16–22.
Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T: The 70 kDa peroxisomal membrane protein is a member of the MDR (P-gly-coprotein)-related-ATP binding protein super-family. J Biol Chem 1993;265:4534–4540.
Lombard-Platet G, Savary S, Sarde CO, Mandel JL, Chimini G: A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Proc Natl Acad Sci USA 1996;93:1265–1269.
Luciani MF, Denizot F, Savary S, Mattei MG, Chimini G: Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics 1994;21:150–159.
Kamijo K, Kamijo T, Ueno I, Osumi T, Hashimoto T: Nucleotide sequence of the human 70kda peroxisomal membrane protein: a member of the ATP-binding cassette transporters. Biochim Biophys Acta 1992;1129:323–327.
Gartner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D: Localization of the 70K peroxisomal membrane protein gene to human 1p21-p22 and mouse 3. Genomics 1993;15:412–414.
De Bry RW, Seidin MF: Human mouse homology relationship. Genomics 1996;33:337–351.
Gyapay G, Schmitt K, Fizames C, Jones H, Vega-Czarny N, Spillett D, Muselet D, Prud’homme JF, Dib C, Auffray C, Morissette J, Weissenbach J, Goodfellow P: A radiation hybrid mapping of the human genome. Hum Mol Genet 1996;5:339–346.
Krauter K, Montgomery K, Yoon SJ, LeBlanc-Straceski J, Renault B, Marondel I, Herdman V, Cupelli L, Banks A, Lieman J, Menninger J, Bray-Ward P, Nadkarni P, Weissenbach J, Les-Paslier D, Rigault P, Chumakov K, Cohen D, Miller P, Ward D, Kucherlapati R: A second generation YAC contig map of human chromosome 12. Nature 1995;377:321S–334S.
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This work was supported by institutional grants from INSERM and CNRS and by a specific grant from the GREG.
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Savary, S., Troffer-Charlier, N., Gyapay, G. et al. Chromosomal Localization of the Adrenoleukodystrophy-Related Gene in Man and Mice. Eur J Hum Genet 5, 99–101 (1997). https://doi.org/10.1007/BF03405885
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DOI: https://doi.org/10.1007/BF03405885
