Figure 5
From: The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications
Example of multi-functional IONPs used for drug delivery and as MRI contrast agents. (Top) T2-weighted MR images (4.7 T, spin echo acquisition, TR = 6000 ms, TE = 90 ms) of Ste20-like kinase (SLK) cells, untreated (left) and treated (right) with 16% cRGD-doxorubicin-IONPs micelles at an iron concentration of 25 μg mL −1. (Middle) Schematic representation of IONPs stabilized using an amphiphilic polymer (poly(ethylene glycol)-block-poly(D,L-lactide)). The hydrophobic core encapsulates doxorubicin as a therapeutic agent, and the particles are decorated with a targeting agent (c-RGD peptide). The transmission electronic microscopy (TEM) images (cryo-TEM inset) show doxorubicin-IONP-loaded polymeric micelles. (Bottom) Fluorescence microscopy of cell uptake of IONPs in SLK cells with and without c-RGD peptide using doxorubicin as a fluorescence label. Adapted from Ref. 34 (© 2005 ACS).
