Figure 2
From: Scaffolded biosensors with designed DNA nanostructures
Impact of probe layer structure. (a) Schematic illustration of an ideal DNA recognition layer with large interprobe distances and upright conformation. (b) Densely packed DNA probes with an upright conformation, but resulting in poor hybridization efficiency that is due to steric hindrance. (c) Probes tend to lie flat on the surface owing to nonspecific adsorption in the sparse film. (d) Mixed single-stranded (ss)DNA/alkylthiol monolayers.
