Figure 8

(A) (top) Schematic illustration for pH-triggered release of the anticancer drug from β-cyclodextrin-modified cerium oxide nanoparticle (β-CD@CeONP) capped ferrocene-functionalized mesoporous silica nanoparticle (Fc-MSN) to the cytosol. (below) The different enzymatic activities of CeONP at different pH values could make it be a cell protector or a cell killer.¹⁶ Copyright 2013, Wiley-VCH. (B) (top) Schematic representation of H₂O₂-fueled release of guest molecule clioquinol (CQ) from the pores of MSN capped with CeONP. CQ can sequester Cu²⁺ from amyloid β-peptide (Aβ), inhibiting aggregation. CeONP can protect cells from oxidative stress. Below: scanning electron microscopic images representing morphological observations performed on Aβ–Cu²⁺-treated differentiated PC12 cells. (a) Control, (b) Aβ–Cu²⁺ complex, (c) Aβ–Cu²⁺ complex with glucose-coated CeONP (G-CeONP) and (d) Aβ–Cu²⁺ complex with MSN–CQ–G-CeONP.¹⁷ Copyright 2013, Royal Society of Chemistry.