Figure 1
From: Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

Construction of fluorescent DNA nanodevices on target living cell surfaces based on an aptamer-tethered DNA nanodevice platform, where (a) three types of fluorescent DNA nanodevices, preformed via hybridization chain reaction (HCR)-based self-assembly upon initiation by aptamer-tethered trigger probes, are anchored on target cell surfaces, or (b) aptamer seed probes initiate in situ self-assembly of fluorescent DNA nanodevices on target cell surfaces by either (i) cascading alternative hybridization of two partially complementary monomers or (ii) HCR (adapted from Zhu et al.19).