Figure 4 | NPG Asia Materials

Figure 4

From: Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery

Figure 4

Drug-DNA adducts for targeted anticancer drug delivery in vitro. (a and b) Flow cytometry data showing the selective recognition of sgc8-Dox adduct to target CEM cells (a), but not to nontarget Ramos cells (b). (sgc8: Biotinylated; lib: random sequences) (c) confocal laser scanning microscopy images displaying the intracellular behaviors of sgc8-doxorubicin adduct (2-μM doxorubicin equivalents) in CEM cells after treatment for 1 and 2 h, respectively. (sgc8: labeled with Cy5; insets: enlarged cells; inset scale bar: 20 μm.) (d and e) MTS assay results indicating selective cytotoxicity of sgc8-doxorubicin adduct in CEM cells (d), but much less in Ramos cells (e).

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