Figure 8

(a) Schematic illustration of a multifunctional NP self-assembled by a representative porphyrin-telodendrimer, PEG^5k-Por₄-CA₄, composed of four pyropheophorbide-a molecules and four cholic acids attached to the terminal end of a linear PEG chain. (b) Schematic illustration of NPs as a smart ‘all-in-one’ nanomedicine platform against cancers. (c) TEM image of NPs (stained with phosphotungstic acid, PTA). (d) The absorbance spectra of NPs before and after chelating different metal ions. (e) Fluorescence emission spectra of NPs in the presence of PBS (red) and SDS (blue). Excitation: 405 nm. (f) Near-infrared fluorescence imaging of NP solution (10 μl) in the absence and presence of SDS with an excitation bandpass filter at 625/20 nm and an emission filter at 700/35 nm. (g) Single oxygen generation of NPs in PBS and SDS upon light irradiation (690 nm at 0.25 W cm⁻² for 60 s) measured by using SOSG as an indicator (n=3). The results are expressed as mean±s.d. Concentration-dependent photothermal transduction of NPs: (h) thermal images and (i) quantitative temperature change curve (n=2). The results are expressed as mean±s.d. The temperature of NP solution (10 μl) in the absence and presence of SDS was monitored by a thermal camera after irradiation with NIR laser (690 nm) at 1.25 W cm⁻² for 20 s.⁸⁵