Figure 5

In vivo magneto thermal performance of perfluorohexane-hollow iron oxide nanoparticles (PFH-HIONs) and the corresponding magnetic droplet vaporization (MDV) process for contrast-enhanced ultrasound imaging. (a) Thermal images of mice after the administration of (1′) saline, (2′) PFH, (3′) HIONs and (4′) PFH-HIONs. (b) Quantitative temperature time curve of tumor tissue corresponding to thermal images of (a). (c) In vivo ultrasound imaging of tumors before and after the administration of (a) PFH-HIONs, (b) HIONs and (c) saline, and the subsequent exposure to the a.c. magnetic field. (d) In vivo quantitative gray values of tumor corresponding to the images of (c).