Figure 6
In vivo magnetic hyperthermia of tumor assisted by the performance of perfluorohexane-hollow iron oxide nanoparticles (PFH-HIONs). Photographs of tumors after the administration of (a) saline, (b) HIONs and (c) PFH-HIONs, and subsequent magnetic hyperthermia for 3 min. The images were recorded before and after the treatments for 4 and 14 days. (d) Photographs of tumors obtained by surgical removal after the administration of saline (left image), HIONs (middle image) and PFH-HIONs (right image) and subsequent magnetic thermal ablation. (e) Tumor growth curve of volume after the treatment of saline as the control, HIONs and PFH-HIONs as the therapeutic group, and further magnetic hyperthermia. (f) H&E staining and (g–j) optical microscopic images of immunohistochemical staining of tumor slices after the treatment by saline, HIONs and PFH-HIONs, and further magnetic hyperthermia. (g: PCNA, h: TUNEL, i: Bcl-2 and j: caspases).
