Figure 7 | NPG Asia Materials

Figure 7

From: Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Figure 7

(a) Tumor volume and (b) body weight comparisons of mice following intravenous administration of different samples (that is, control, DOX, nGO@DOX-cPEG and nGO@DOX-cPEG+NIR) in PC3 tumor-bearing BALB/c nude mice. Each sample was administered three times at 3-day intervals (*P<0.05, **P<0.01, ***P<0.001). (c) Immunohistopathological and immunohistochemical analyses. Representative changes in tumor histopathology and immunoreactivity to caspase-3, PARP, CD31 and Ki-67 in tumor masses of nude mice from treatments are shown. Caspase-3 and PARP are markers for apoptosis and CD31 and Ki-67 are markers for angiogenesis. Scale bar, 120 μm. cPEG, chitosan-polyethylene glycol; Cy5.5, cyanin 5.5; DOX, doxorubicin; nGO, nanodimensional graphene oxide; NIR, near-infrared; PARP, poly(-ADP-ribose) polymerase.

Back to article page