Figure 2
From: A biomimetic design for a sialylated, glycan-specific smart polymer
Dynamic adsorption curves of various monosaccharides or sialo-trisaccharides on a polyethyleneimine-grafted-L-aspartate-L-phenylalanine dimethyl ester (PEI-g-DF) thin film monitored by a quartz crystal microbalance with dissipation (QCM-D). (a–d) Comparison of the time-dependent QCM frequency changes of the saccharides adsorbed on the PEI-g-DF-modified QCM resonators; (a) glucose homologs (three important biological hexoses), namely, Glc, Man and Gal; (b) core monosaccharide building blocks of complex-type N-linked glycan: Neu5Ac, GlcNAc and Gal; (c) Neu5Ac and its sodium salt; (d) glycosidic linkage isomers of sialyllactose, and their chemical structures are shown in f. (e) Comparison of the time-dependent dissipation changes of 3′- and 6′-sialyllactose on the PEI-g-DF-modified resonators. Saccharide concentrations: 50 mM; solvent: pure water, flow rate: 0.200 ml min−1; temperature: 25 °C.
