Figure 3
From: A biomimetic design for a sialylated, glycan-specific smart polymer
Dynamic adsorption curves of the various monosaccharides or sialo-trisaccharides on a polyethyleneimine-grafted-L-aspartate-L-phenylalanine dimethyl ester (PEI-g-DF) thin film monitored by a quartz crystal microbalance with dissipation. Surface morphology and stiffness changes of PEI-g-DF. (a–d) Surface morphologies of the PEI-g-DF thin film before (a) and after treatment with Neu5Ac sodium salt (b), Gal (c) or 3′-sialyllactose sodium salt (d) solutions with a concentration of 50 mM at 25 °C detected by an AFM in a peak force quantitative nano-mechanical (PFQNM) mode. The section profiles along the green lines in the AFM images are shown in the bottom layers. (e, f) Young’s modulus images of the polymer film before (e) and after treatment with a 3′-sialyllactose sodium salt solution (f) as well as the distribution of the Young’s moduli corresponding to the images. Scale bar: 1 μm.
